新聞中(zhōng)心
華南(nán)師範大(dà)學生(shēng)物(wù)光子學院黎錦明課題組在《ACS Nano》雜(zá)志(zhì)上發表了題爲“Near-Infrared Light-Controlled and Real-Time Detection of Osteogenic Difffferentiation in Mesenchymal Stem Cells by Upconversion Nanoparticles for Osteoporosis Therapy”文章。
團隊開(kāi)發了一(yī)種新型納米載體(tǐ)UCNP@mSiO2-peptide-BHQ-ONA-CD。這種納米載體(tǐ)被MSC細胞内吞後,被980nm近紅外(wài)光激發,可釋放(fàng)icariin 促進MSC細胞向成骨細胞分(fēn)化來治療骨質疏松症,相對于傳統方法效果顯著。
其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備ChemiScope 6100進行核酸檢測和蛋白(bái)印迹分(fēn)析,使用勤翔(Clinx)小(xiǎo)動物(wù)活體(tǐ)成像設備IVScope 8000記錄成像結果。
Cell Discovery
西安交通大(dà)學徐峰教授、美國聖路易斯華盛頓大(dà)學Guy. M. Genin教授團隊在《Cell Discovery》發表題爲“A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype”文章。
研究利用集成的體(tǐ)外(wài)和計算機模拟,發現整合素β1和Piezo1活化之間存在一(yī)個相互增強的機械正反饋回路,以形成一(yī)個雙穩态開(kāi)關。雙穩态開(kāi)關由基質彈性模量的擾動啓動,該擾動被放(fàng)大(dà)以觸發涉及Ca2+和YAP的下(xià)遊信号傳導,從而遞歸地導緻成纖維細胞進一(yī)步硬化其環境。通過同時幹擾新發現的機械正反饋回路和調節基質彈性模量,研究人員(yuán)逆轉了CF表型轉變的标志(zhì)物(wù),爲纖維化疾病提供了新的治療靶點。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像系統來量化曝光的蛋白(bái)質條帶。
Acta Pharmaceutica Sinica B
四川大(dà)學華西藥學院孫遜教授團隊在《Acta Pharmaceutica Sinica B》發表題爲“Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity”文章。
現有COVID-19疫苗的長期保護和對新變種效力的顯著降低,流行病預防和控制仍具挑戰。研究基于 CASE 制造了一(yī)種腺相關病毒血清6型疫苗(S663V-RBD),單劑量 S663V-RBD 在小(xiǎo)鼠中(zhōng)誘導更持久強大(dà)的免疫應答,并引發針對三種典型 SARS-CoV-2假病毒(包括野生(shēng)型 C.37(Lambda)和 B.1.617.2(Delta))的優異中(zhōng)和抗體(tǐ),基于CASE的S663V-RBD可能會爲當前和下(xià)一(yī)次流感大(dà)流行提供新的解決方案。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像系統進行蛋白(bái)信号成像。
Nature Communications
西安交通大(dà)學馮智輝教授團隊在《Nature Communications》上發表題爲“Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy”文章。
研究成果指出SDHAF4在心髒應激過程參與心肌功能調控的新機制,并表明補充SDH底物(wù)富馬酸鹽或Drp1的抑制劑(Mdivi-1)靶向幹預線粒體(tǐ),可以顯著改善線粒體(tǐ)動力學和心髒功能,并延長心肌梗死模型(MI)小(xiǎo)鼠和DCM小(xiǎo)鼠的壽命。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備進行蛋白(bái)印迹成像與分(fēn)析。
One Health Implement Res.
尼日利亞醫學研究所分(fēn)子寄生(shēng)蟲學研究實驗室Olaoluwa P.Akinwale教授團隊在《One Health & Implementation Researchature》上發表題爲“Characterization of freshwater snail intermediate hosts of schistosomes in four communities from Osun State, Southwest Nigeria”文章。
這項研究證實了,由于淡水蝸牛在形态和内在特征上缺乏獨特性,很難用傳統的方法從泡螺屬種群内對其進行鑒别和區分(fēn),而RFLP是一(yī)種更便宜的測序替代方法,可用于資(zī)源有限的實驗室進行泡螺屬種類的鑒别。其中(zhōng),研究團隊使用勤翔(Clinx)凝膠成像系統對DNA片段數量及大(dà)小(xiǎo)進行成像記錄。
Signal Transduct Target Ther.
四川大(dà)學馬良和付平研究團隊在《Signal Transduction and Targeted Therapy》發表題爲“FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury”文章。
研究指出FFAR4首次被發現在急性腎損傷小(xiǎo)鼠和腎小(xiǎo)管上皮細胞中(zhōng)調節細胞衰老,爲FFAR4可能是治療AKI的一(yī)個希望靶點,提供了有力證據。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備進行蛋白(bái)印迹成像分(fēn)析。
Nano Letters
華南(nán)師範大(dà)學生(shēng)物(wù)光子學院黎錦明課題組在《Nano Letters》雜(zá)志(zhì)上發表了題爲“Near-Infrared Light-Controlled Activation of Adhesive Peptides Regulates Cell Adhesion and Multidifffferentiation in Mesenchymal Stem Cells on an Up-Conversion Substrate”文章。
這項重要研究成果,開(kāi)發了一(yī)種控制細胞粘附和多分(fēn)化的新方法,将來有望應用于光再生(shēng)醫學領域。
其中(zhōng),研究團隊使用勤翔(Clinx)小(xiǎo)動物(wù)活體(tǐ)成像設備IVScope 8000進行活體(tǐ)實驗,觀察小(xiǎo)鼠背部熒光強度的變化。
Acta Biomaterialia
浙江大(dà)學高長有教授、浙江大(dà)學醫學院第一(yī)附屬醫院曹紅翠教授團隊在《Acta Biomaterialia》上發表“ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment”文章。
團隊開(kāi)發了一(yī)種納米粒子:PFTU@DEX NPs,它可減少使用昂貴的材料,以及可能對在臨床中(zhōng)采用中(zhōng)高劑量藥物(wù)減負。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備進行蛋白(bái)印迹成像。
Bioactive Materials
中(zhōng)國科學院甯波材料所吳愛國團隊在《Bioactive Materials》雜(zá)志(zhì)發表題爲“Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis”文章。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備ChemiScope 6200Touch進行蛋白(bái)印迹成像與觀察。
Acta Biomaterialia
蘇州大(dà)學張明陽教授和陶陸陽教授、南(nán)京醫科大(dà)學附屬蘇州醫院單海燕團隊在《Acta Biomaterialia》雜(zá)志(zhì)上發表“Surface-fifill H2S-releasing silk fifibroin hydrogel for brain repair through the repression of neuronal pyroptosis”文章。
該研究開(kāi)發了一(yī)種裝載H2S可注射填充絲素蛋白(bái)的水凝膠:H2S@SF hydrogel,對重度腦出血治療提供了局部、小(xiǎo)劑量給藥的新模式。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像系統用于檢測免疫反應條帶。
Nature Communications
北(běi)京化工(gōng)大(dà)學羅施中(zhōng)教授團隊在《Nature Communications》上發表題爲“Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate”文章。
該文首次揭示了堿性成纖維生(shēng)長因子(bFGF)可以在細胞膜表面硫酸乙酰肝素的作用下(xià)發生(shēng)細胞外(wài)液液相分(fēn)離(lí)(LLPS),進而實現下(xià)遊信号通路的激活,這一(yī)新的發現爲細胞外(wài)膜上蛋白(bái)質相分(fēn)離(lí)的相關研究提供了新的理論及實驗依據。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像設備進行蛋白(bái)印迹成像分(fēn)析。
INT J BIOL SCI
四川大(dà)學黃燦華教授、成都中(zhōng)醫藥大(dà)學姜岑教授、澳大(dà)利亞莫納什大(dà)學Edouard Nice教授團隊等在《International Journal of Biological Sciences》發表“Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest”文章。其中(zhōng),研究團隊使用了勤翔(Clinx)化學發光成像系統進行了蛋白(bái)印迹成像。
Advanced Science
中(zhōng)國科學院生(shēng)物(wù)物(wù)理研究所閻錫蘊課題組在《Advanced Science》發表題爲“CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity”文章
該研究闡明了高脂環境下(xià)的巨噬細胞極化機制,并且爲肥胖相關代謝綜合征的治療提供了新的治療靶标。其中(zhōng),研究團隊使用勤翔(Clinx)化學發光成像系統進行蛋白(bái)印迹成像分(fēn)析。
以下(xià)文獻(2022不完全統計)全部标注使用了勤翔(Clinx)産品:
- Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement,Nature Communications
- ATF4-dependent fructolysis fuels growth of glioblastoma multiforme,Nature Communications
- A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages,Nature Communications
- Gene activation guided by nascent RNA-bound transcription factors,Nature Communications
- A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant,Nature Communications
- Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY,Nature Communications
- Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion,Nature Communications
- Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation,Nature Communications
- Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading,Nature Communications
-Tumour-derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour-homing and intracellular freeway transportation,Journal of extracellular vesicles
- Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs,Signal Transduction and Targeted Therapy
- Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma,Bioactive Materials
- Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits,Advanced Science
- Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus,Science advances
- Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity,International Journal of Biological Sciences
- Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma,International Journal of Biological Sciences
- Oncolytic peptide LTX-3 15 induces anti-pancreatic cancer immunity by targeting the ATP11B- PD- L1 axis,Journal for immunotherapy of cancer
- STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth,Journal of experimental & clinical cancer research
- Human tau accumulation promotes glycogen synthase kinase-3b acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration,EBioMedicine
- SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulffdes with ER oxidoreductases,Redox Biology
- MPST deffciency promotes intestinal epithelial cell apoptosis and aggravates inffammatory bowel disease via AKT,Redox Biology
- Kiwifruit MYBS1-like and GBF3 transcription factors influence L-ascorbic acid biosynthesis by activating transcription of GDP-L-galactose phosphorylase 3,New phytologist
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